Phenytoin narrow therapeutic index
WebJun 18, 2009 · In North Carolina, General Statute (NCGS) 90-85.27 defines NTI drugs to mean those pharmaceuticals having a narrowly defined range between risk and benefit. 2 Drugs identified as having NTIs ( TABLE 2) are … WebPhenytoin is a long-standing, anti-seizure drug widely used in clinical practice. It has also been evaluated in the context of many other illnesses in addition to its original epilepsy …
Phenytoin narrow therapeutic index
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WebExplanation: FDA has concluded that phenytoin is a narrow therapeutic index (NTI) drug based on the following evidence: • The range between the effective phenytoin concentrations and the concentrations associated with serious toxicity is narrow • Sub-optimal doses or concentrations lead to therapeutic failure or severe toxicity
WebClinically significant interactions can occasionally occur due to weak inhibitors and inducers (eg, target drug is highly dependent on CYP3A4 metabolism and has a narrow therapeutic index). Accordingly, specific interactions should be checked using a drug interaction program such as the Lexicomp drug interactions program included within UpToDate. WebNarrow Therapeutic Index Drugs Accession Number DBCAT003972 Description. Narrow therapeutic index (NTI) drugs are defined as those drugs where small differences in dose …
WebSep 29, 2014 · Phenytoin is an antiepileptic drug (AED) indicated for control of generalized tonic-clonic and complex partial seizures. While neurologists consider most AEDs as NTI … WebMay 8, 2024 · However, warfarin falls in the narrow therapeutic index drug category and is subject to numerous interactions. This activity outlines the indications, mechanism of action, interactions, significant adverse effects, contraindications, toxicity, and warfarin monitoring so providers can direct patient therapy where anticoagulation is indicated as ...
WebJan 1, 2024 · Discussion. Therapeutic drug monitoring (TDM) is used to tailor medication dosing when drugs (1) have a narrow therapeutic index, (2) display variable pharmacokinetics, or (3) their efficacy and/or toxicity is challenging to assess early in the therapeutic course [1].Phenytoin is a prevalent anticonvulsant medication used to …
WebSome of the drugs, metabolized by CYP2C9 have narrow therapeutic index eg warfarin, phenytoin, and tolbutamide. This is the reason that small change in the metabolizing activity of CYP2C9 may cause major changes in an individual’s response against a drug. kuching motorcycle rentalWebPhenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation in CYP2C9. Furthermore, the variant allele HLA-B*15:02 is associated with an increased risk of Stevens–Johnson syndrome and toxic epidermal necrolysis in response to phenytoin treatment. kuching pictureWebPhenytoin has a narrow therapeutic index and small changes in dose or in metabolic capacity e.g. due to intercurrent illness or hepatic impairment may cause large … kuching pcr testWebPhenytoin has a narrow therapeutic index and the relationship between the dose and serum concentration of phenytoin is non-linear (BNF, 2024). A little increased dose can produce a bigger plasma concentration proportionally, even within the plasma concentration therapeutic range. The half-life is varied and kuching office suppliesWebMar 21, 2024 · This drug should be considered a narrow therapeutic index (NTI) drug as small differences in dose or blood concentrations may lead to serious therapeutic failures or adverse drug reactions. Recommendations: Generic substitution should be done cautiously, if at all, as current bioequivalence standards are generally insufficient for NTI drugs. kuching night clubWebPhenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants. 12,6,8 Since it's introduction about 80 … kuching pronunciationWebAbstract. Phenytoin, which is used primarily as an anticonvulsant agent, has a relatively low therapeutic index, and monitoring of plasma phenytoin concentration is often used to … kuching north city hall