Human ether-a-go-go-related gene
WebhERG. ヒト心臓の心筋に発現しているhERG（human ether-a-go-go related gene）から発現するタンパク質のことで，心筋活動電位の再分極を担うカリウムイオンチャネルで … WebThe human Ether-à-go-go-Related Gene was so named because when Drosophila flies with mutations in the Ether-à-go-go gene are anaesthetised with ether, their legs start to shake, like the dancing at the then popular Whisky a Go Go nightclub. See also. Los Angeles portal; Live at the Whisky a Go Go (disambiguation)
Human ether-a-go-go-related gene
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Web14 okt. 2012 · hERG的全称是human ether-a-go-go related gene。它是从人的海马神经中分离出来的基因。hERG基因编码形成电压激活延迟内向整流的钾离子通道（Ikr）,大量分 … WebWe have previously reported that a long-lasting activation of human ether-a-go-go-related gene (hERG) K + channels occurs in neuronal and hemopoietic tumor cells after integrin …
Web5 mei 2008 · May 5, 2008. #2. "Ether-a-go-go" is part of the name of of the hERG (a gene). hERG stands for " h uman E ther-a-go-go R elated G ene." Here's the explanation from … Web1 mrt. 2024 · Background. KCNH2 encodes the human ether-à-go-go-related gene potassium channel, which passes the rapid delayed rectifier potassium current. Loss-of-function variants in KCNH2 cause long QT syndrome type 2, which is associated with a markedly increased risk of cardiac arrhythmias. The majority of rare KCNH2 variants, …
WebThe human ether-a-go-go-related voltage-gated cardiac ion groove (commonly acknowledged as hERG) directs the rapid outward repolarizing potassium running in cardiomyocytes (IKr). Inadvertent blockade of this channel by drug-like minims represents a key challenge in pharmaceutical R&D due to often intersecting between the structure … WebAN OVERVIEW ON HUMAN ETHER-A-GO-GO-RELATED GENE ASSAY Abstract hERG (human ether-à-go-go-related gene) encodes a potassium ion channel which involved …
Web28 sep. 2007 · Abstract. Antipsychotic drugs are thought to exert their therapeutic action by antagonizing dopamine receptors but are also known to produce side effects in the heart by inhibiting cardiac ether-a-go-go–related gene (ERG) K + channels. Recently, it has been discovered that the same channels are present in the brain, including midbrain dopamine …
WebOur previous study of the human ether-à-go-go related gene (hERG)-encoded K + channel (K v 11.1) supports an association between hERG and RING finger protein 207 (RNF207) variants in aggravating the onset and severity of LQTS, specifically T613M hERG (hERG T613M) and RNF207 frameshift (RNF207 G603fs) mutations. glasses mounted action cameraWeb25 jul. 2024 · Gene name - ether a go-go. Synonyms - . Cytological map position - 13A2-13A5 . Function - voltage gated K+ channel. Keywords - a voltage-gated delayed rectifier … glasses on top of glassesWebUnfortunately, 1 has potent human ether-a-go-go-related gene (hERG) inhibitory activity, associated with long Q–T syndrome, and consequently presents a cardiotoxicity risk. Here, we describe the identification of an optimized Tg CDPK1 inhibitor 32 , which does not have a hERG liability and possesses a favorable pharmacokinetic profile in small and large … glasses mounted display removablehERG (ヒト遅延整流性カリウムイオンチャネル遺伝子, human Ether-a-go-go Related Gene) とは、心筋活動電位の再分極を担う、 カリウムイオンチャンネルKv11.1をコードする遺伝子である。 glasses medicaid nhWeb23 sep. 2016 · The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr), which is … glasses motorcycle helmetWebIn vivo and in vitro studies have found that LQTS mutations are associated with cardiomyocyte apoptosis, cardiac developmental disorders and even embryonic … glasses necklace chainWeb3 mei 2024 · Miaomaio Liu, Yakun Yang, Muqing Zhang, Yucong Xue, Bin Zheng, Yuanyuan Zhang, Yu Liu, Xi Chu, Zhenqing Sun, Xue Han, Inhibition of human ether-à-go-go … glasses middlesbrough cannon park