Hepatocyte nuclear factor 4α

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August undefined, 2024

WebMutations in hepatocyte nuclear factor 4α (HNF4α) gene associated with diabetes result in greater loss of HNF4α function in pancreatic β-cells than in nonpancreatic β-cells and in … WebThis data indicates that HNF4α regulates intestinal epithelial NHE3 expression and may have implications for progeriaigenicity, which is a major determinant of bowel cancer …

Hepatocyte nuclear factor-4alpha contributes to carbohydrate …

Web21 mrt. 2024 · HNF4A (Hepatocyte Nuclear Factor 4 Alpha) is a Protein Coding gene. Diseases associated with HNF4A include Fanconi Renotubular Syndrome 4 With … Web15 mrt. 2024 · Down-regulation of hepatocyte nuclear factor-4α expression and defective zonation in livers have not been recognized so far as features of the liver disease caused … bob costas fired nbc

HNF4A gene: MedlinePlus Genetics

WebThe transcription factor HNF4α (hepatocyte nuclear factor-4α) is required for increased β-cell proliferation during metabolic stress in vivo. We hypothesized that HNF4α could … WebHepatocyte nuclear factor 4α (HNF4α) is a nuclear transcription factor that binds DNA as a homodimer. HNF4α controls the expression of several genes, including HNF1α, a … WebTo date, mutations associated with MODY have been reported in least 14 different genes, 5–14 including the following six genes encoding major factors: hepatocyte nuclear … clip art alice in wonderland characters

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Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats

WebHepatocyte nuclear factor 4α (HNF4α), an important transcriptional factor of the nuclear hormone receptor family, is essential for normal liver architecture, morphological and … WebHepatocyte nuclear factors (HNFs) are a family of transcription factors that regulate liver-specific gene expression and hepatocyte differentiation [11–14].Some HNFs (HNF1α, … clip art alligator black and whiteWeb23 okt. 2024 · Hepatocyte nuclear factor 4α (HNF4α) is highly enriched in the liver, but its role in the progression of nonalcoholic liver steatosis (NAFL) to NASH has not been … bob costas health

"WebThe hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, … " - Hepatocyte nuclear factor 4α

Hepatocyte nuclear factor 4α

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WebHepatocyte nuclear factor 4α (HNF-4α) is a liver-enriched transcription factor which, together with other factors, plays a key role in the tissue-specific expression of a large … WebMultiple nuclear receptors, including hepatocyte nuclear factor 4α (HNF4α), retinoid X receptor α (RXRα) plus peroxisome proliferator-activated receptor α (PPARα), RXRα …

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WebHNF-4α is a highly conserved transcription factor that has the potential capacity to transactivate a vast number of genes, including CYP7 which codes for cholesterol 7α … WebThe expression level of DD4 mRNA significantly correlated with that of HNF-1α, HNF-4α or HNF-4γ. These results suggest that the expression level of DD4 mRNA is cooperatively …

Web5 sep. 2024 · Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates … Web1 mrt. 2011 · CYP3A41 is a female-specific cytochrome P450 in mouse liver. A putative hepatocyte nuclear factor 4α (HNF4α)-binding site was found at −99/−87 in the …

WebThe HNF-4α protein acts as a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. The HNF-4α … WebHere, we demonstrate that the Caenorhabditis elegans R-Smad DAF-8 partners with the nuclear hormone receptor NHR-69, a C. elegans ortholog of mammalian hepatocyte …

Web22 okt. 2024 · Hepatocyte nuclear factor 4 alpha (HNF4α) is a key master transcriptional factor for hepatic fat and bile acid metabolic pathways. We aimed to investigate the role …

Web1 mrt. 2009 · Hepatocyte nuclear factor-4α (HNF4α) is a nuclear receptor superfamily which plays an important role in early hepatocytes development [2]. HNF4α is a master … bob costas health problems 2018WebHepatocyte nuclear factor 4α (HNF4α) is a nuclear hormone receptor that is highly expressed in hepatocytes. Hepatic HNF4α expression is markedly reduced in NAFLD … clip art alice in wonderland tea party clipart alligator black and whiteWebChromosomal abnormalities, epigenetic alterations, and environmental factors may contribute to the pathogenesis of CRC. ... PTB1/PKM1/PKM2 feedback cascade, 16 … bob costas family photosWeb10 aug. 2009 · Background and aims Hepatocyte nuclear factor 4α (HNF4α) is a central transcriptional regulator of hepatocyte differentiation and function. The aim of this study … clip art alligators freeWeb29 sep. 2010 · Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that plays a key role in hepatocyte differentiation and the maintenance of hepatic function, but its … clip art all souls dayWebA combination of adenoviral transfections for CCAAT/enhancer-binding protein β (C/EBPβ), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor (CAR) … bob costas hometown