Cytoplasmic retention signal
WebJul 11, 2013 · N-terminal deletions (Δ2–41 and Δ2–109) destroyed the cytoplasmic retention signal. Thus, SAMHD1K11A is cytoplasmic, yet SAMHD1 (Δ2–41 and Δ2–109) mutants could still be detected in the … WebNational Center for Biotechnology Information
Cytoplasmic retention signal
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WebOct 19, 2005 · Distribution of YB-1 between the nucleus and the cytoplasm is known to be dependent on nuclear targeting and cytoplasmic retention signals located within the C-terminal portion of YB-1. WebSignal-Based Retention of Golgi Resident Proteins via Carboxy-Terminal Lysine-Based Motifs The glycosylation of proteins and lipids depends on nucleotide-sugar conjugates that are translocated from the cytoplasm into the lumen of the ER or Golgi via multispanning membrane proteins called nucleotide-sugar transporters (NSTs) ( Berninsone and ...
WebMar 30, 2024 · The Pest-Like Sequence of IκBα Is Responsible for Inhibition of DNA Binding but Not for Cytoplasmic Retention of c-Rel or RelA Homodimers. Mary K. Ernst Laboratory of Molecular ... suggesting that it may perform the same function in cells when the activating signal is no longer present. Structurally, the human I κ Bα molecule can be divided ... WebOct 13, 1995 · The ER retention signal of the cytoplasmic domain could not be localized to a single amino acid segment by deletion analysis. These results show that cytochrome P450 2C2 contains redundant, complex ER retention signals in its cytoplasmic and N-terminal hydrophobic domains and that the function of the N-terminal signal is context …
WebThe majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown biological significance. ... DDX3 mutants were created for in vitro evaluation of the mechanism behind nuclear retention of DDX3.Results: DDX3 was present in the nucleus of 35% of colorectal and 48% of breast cancer ... WebAug 1, 1997 · The JNK signal transduction pathway is activated in response to environmental stress and by the engagement of several classes of cell surface receptors, including cytokine receptors, serpentine receptors, and receptor tyrosine kinases ( 1 ). Genetic studies of Drosophila have demonstrated that JNK is required for early …
WebCytokine release syndrome (CRS) is a form of systemic inflammatory response syndrome (SIRS) that can be triggered by a variety of factors such as infections and certain drugs. …
WebMar 1, 2004 · Cytoplasmic retention of signal transducers prevails when cells are poised to receive an extracellular signal, and nuclear … portnoy pittsburghWebAug 1, 1994 · Although the cytoplasmic retention signal region is outside the cyclin box, its sequence is well conserved in human cyclin B2, and is both necessary and sufficient … portnoy\\u0027s creator crossword clueWebDec 7, 2024 · Combined with the genetic and microscope-based approaches, two types of the functionally coupled and evolutionally conserved localization regulatory motifs are identified, including the... portnoys complaint rotten tomatoesWebIn this review, the main sequence features that dictate whether any particular mRNA or lncRNA is a substrate for retention in the nucleus, or export to the cytoplasm, are … optionsmembers co ukWebSep 1, 1994 · Although the cytoplasmic retention signal region is outside the cyclin box, its sequence is well conserved in human cyclin B2, and is both necessary and sufficient to keep cyclin B2 in the cytoplasm. optionsmembers.co.ukWebOct 29, 2024 · Our results also show that Transportin-2 (TNPO2, importin-3) enhances the cytoplasmic localisation of ERα, not as a nuclear export receptor, but rather as a cytoplasmic retention factor, while it ... optionsmasterWebMay 17, 2005 · Nucleocytoplasmic Shuttling with Periods of Retention: Smads Smad proteins are a family of inducible transcription factors that mediate signals from the transforming growth factor–β (TGF-β) superfamily of ligands, including TGF-β and bone morphogenetic protein (BMP). portnuef library chubbuck e audio books